Neuroimaging and Neurodevelopmental Outcome in Extremely Preterm Infants
Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Pediatrics Vol. 135 No. 1 January 1, 2015
In extremely preterm infants who are at risk for neurodevelopmental impairment (NDI ) near-term brain MRI has been reported to better predict outcomes. Of 480 infants studied retrospectively. Increasing severity of WMA and significant cerebellar lesions on MRI were associated with adverse outcomes. Cerebellar lesions were rarely identified by CUS.
CONCLUSIONS: Both late CUS and near-term MRI abnormalities were associated with outcomes, independent of early CUS and other factors, underscoring the relative prognostic value of near-term neuroimaging.
Presepsin for the Detection of Late-Onset Sepsis in Preterm Newborns
Careggi University Hospital of Florence, Florence, Italy
Article published in Pediatrics in Jan 2015 edition.
The objective of this study was to evaluate the accuracy of presepsin (P-SEP) (LIKE CRP) as novel biomarker of bacterial infection for the diagnosis of LOS in preterm newborns. P-SEP had a borderline reduction at day 1 versus values at baseline, whereas CRP and procalcitonin at day 1 did not differ from baseline values. CONCLUSIONS: We demonstrated for the first time in a cohort of preterm newborns that P-SEP is an accurate biomarker for the diagnosis of possible LOS and may also provide useful information for monitoring the response to therapeutic interventions.
Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A Systematic Review – Ireland and Canada study
Article published in Pediatrics in Jan 2015 edition.
Children who experienced IUGR may be at increased risk for adverse developmental outcomes in early childhood. The objective of this study was to carry out a systematic review of neurodevelopmental outcomes from 6 months to 3 years after IUGR.
Evidence suggests that children are at risk for poorer neurodevelopmental outcomes following IUGR from 6 months to 3 years of age.
Safe Sleep in the NICU and at Home
By Renee Poynter, RN, BSN
